8.7.22 – Robert W. Malone, MD

“Paxlovid Escape Mutations?”

President Biden's two and a half-week Covid-19 marathon

By Robert W. Malone, MD, MS


Excerpts from this article:


President Biden continues to harbor the COVID-19 virus (SARS-CoV-2) in his body. He first contracted COVID-19 on July 21, two and a half weeks before the present.

Is this because of immunosuppression - due to his heavily boosted status, or for some other reason?

That being said, the single antiviral drug regime of Paxlovid may also be causing the virus to stay in his body for a long time, an effect otherwise referred to as “the rebound” effect

I believe that the word “rebound” is a misnomer in this context. The virus has never left President Biden’s body. It is still circulating, it was just at a fairly undetectable level for a while. 

Paxlovid manufacturer Pfizer and the Food and Drug Administration have both acknowledged reports of rebound COVID-19 cases associated with the drug.

This is truly the worst case scenario for a single mechanism of an action drug used as a therapy against COVID-19, as described in more detail below.

But it isn’t just that Paxlovid causes the virus to stick around for weeks on end, it doesn’t work very well either:

** 7.22.22 -- “Warning! Biden’s Pushing Paxlovid, the Pfizer Flop Drug” – by M. Dowling – Independent Sentinel -- https://www.independentsentinel.com/warning-bidens-pushing-paxlovid-the-pfizer-flop-drug/

{Upon launch, Pfizer said their new anti-viral drug Paxlovid cut hospitalization and death by 90%. 

An updated, more recent analysis from 1,153 patients (out of a possible 2,246 patients) showed a lackluster, non-significant 51% relative risk reduction…}


How can we control SARS-CoV-2’s evolution of resistance to drugs?

SARS-CoV-2 (the cause of COVID-19) is an RNA virus, just like HIV is an RNA virus.

RNA viruses evolve very rapidly and have a lot of genetic mutations. And just like HIV, the COVID-19 virus evolves so quickly that it evolves right out from under single “mechanism of action” (single agent) drug therapy.

When a patient begins taking Paxlovid, it appears that the drug keeps many of the viruses from reproducing. Because some of the new mutations happen to have a certain level of resistance to the drug, some viruses do survive. Because of COVID-19’s speedy evolution, the virus responds to selection pressures quickly.

So, viruses that happen to survive the drug are favored and then resistant virus strains evolve within the patient.

When a patient is immunosuppressed and doesn’t clear the virus (as seems to be happening with Paxlovid), then this evolution has a longer runway to evolve before the virus is cleared by the body.

These new strains are then spread throughout the population. So, other people can contract the escape-mutant-resistant lineage. A new variant is born.

When HIV single dose therapies failed, physicians soon realized that basic evolutionary theory leads to a solution from this dilemma. That is evolution of resistant viral strains that can be delayed by prescribing a multi-drug therapy. That is why so many early, multi-drug treatment COVID-19 docs use drug cocktails.

So why is it that the FDA, knowing this, did not choose to exclude immunocompromised individuals from using Paxlovid?

[Please go to this 5.13.22 link https://www.covid19treatmentguidelines.nih.gov/therapies/antiviral-therapy/ritonavir-boosted-nirmatrelvir--paxlovid-/  to see the following quote – under Additional Considerations, number 6: 

Severely immunocompromised patients can experience prolonged periods of SARS-CoV-2 replication, which may lead to rapid viral evolution. There are theoretical concerns that using a single antiviral agent in these patients may produce antiviral-resistant viruses. Additional studies are needed to assess this risk. The role of combination antiviral therapy or a longer treatment duration in treating severely immunocompromised patients is not yet known.

Right now, patients consuming the Pfizer drug as a single agent therapeutic are increasing the risk of spawning resistant escape-mutant variants. If you want a case example of how this works - just look to President Biden and his current treatment plan. That is, round three of the current treatment plan. That is two and a half weeks of having circulating virus in his body. That virus is busy evolving to escape the drug and/or his vaccine.

Now, what we learned also from HIV is that the virus mutates so rapidly, that it evolves so quickly, that it evolves right out from under vaccines - particularly in immunosuppressed patients, who do not rapidly clear the virus. Then vaccine-escape mutants are generated which are resistant to the vaccine.

So, the fact that Paxlovid is prolonging the virus in the body can only lead to more vaccine-escape mutants.


8.3.22 – Steve Kirsch Newsletter

WHO IS STEVE KIRSCH?  He is an American multi-millionaire who got his BS and MS in electrical engineering and computer science from MIT.  To name a few:  He and a fellow engineer/scientist invented the first optical mouse.  Kirsch went on to develop a digital identity system tied to cryptography and a widely-used spam filter. He has been an entrepreneur in the marketing of blockchains and of other ground-breaking endeavors. He is independently wealthy, brilliant, and saw through the lies being perpetrated by Dr. Fauci et al. about the COVID pandemic. His “Steve Kirsch Newsletter” carries some of the best COVID medical research available where “he writes about COVID corruption, censorship, mandates, masking, and early treatments…America is being misled by formerly trusted authorities.”

“Why did Biden and Fauci take Paxlovid?”

By Steve Kirsch

They are both full vaccinated which they have assured us protects against severe disease. So why take a drug which has ONLY been approved for people AT RISK for severe disease?

By Steve Kirsch, Executive Director, Vaccine Safety Research Foundation (vacsafety.org)


Critical thinkers might wonder why Biden and Fauci, both fully vaccinated, took Paxlovid. Both men claim that if you are fully vaccinated, it means you are “at low risk for severe disease.” So why would they take any new, unproven drug especially one that is ONLY approved for people who ARE at risk for severe disease.

Something isn’t adding up here.

There are at least three problems with Paxlovid:

  1. It doesn’t work. There wasn’t any statistically significant benefit! But this is 2022 and scientific proof of efficacy isn’t required.
  2. It’s only been tested on unvaccinated people. It may have no effect or a negative effect if you are vaccinated. We don’t know because it has never been tested.
  3. Paxlovid is cleared only for adults and children older than 12 years who are at high risk of severe COVID-19. It’s right there in the EUA: “The FDA has authorized the emergency use of PAXLOVID for the treatment of mild-to moderate COVID-19 in adults and children [12 years of age and older weighing at least 88 pounds (40 kg)] with a positive test for the virus that causes COVID-19, and who are at high risk for progression to severe COVID-19, including hospitalization or death, under an EUA.”

I am left with 4 questions:

  1. Why would Biden and Fauci both take a drug that doesn’t work, that they don’t need, was never properly tested on vaccinated people, and that isn’t approved for their situation?
  2. Why wouldn’t Biden and Fauci take a drug that does work like ivermectin? Ivermectin has much more compelling data on efficacy and safety than paxlovid and it’s statistically significant! Not only that, but there are multiple peer-reviewed meta-analyses and systematic reviews for ivermectin and NONE for Paxlovid. Those are the highest level of evidence-based medicine. 

Check this out from c19early.com:


3. Should we really be taking our healthcare guidance from these leaders who don’t follow instructions and who take untested drugs?

4. If Paxlovid really works, why isn’t Pfizer allowing anyone to do INDEPENDENT clinical trials on it. We have PLENTY of these independent trials for ivermectin! Answer: One of the common tactics pharmaceutical companies do to shield unsafe or ineffective medications they produced fraudulent data for is to refuse to make them available to independent investigators. This is similar to how they make almost all of the data also unavailable for "proprietary reasons."